Poxviruses Have Gene to “Blind” Host Cells’ DNA Sensors

A DNA sensor, the cGAS-STING pathway, is blocked by a cGAMP nuclease encoded by a gene in ectromelia virus, a mouse-specific pathogen that causes mousepox, a lethal disease that resembles human smallpox. The gene is highly conserved among poxviruses, and its action suggests that manipulation of DNA sensing would be an efficient therapeutic strategy in diseases triggered by viral infection or tissue damage–mediated release of self-DNA

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