Neuronal NMDAR-TRPM4 “Death Complex” Disabled by Interface Inhibitors

Conventional NMDA receptor antagonists have failed as therapeutics against neurodegenerative diseases, largely because NMDA receptors contribute to synaptic plasticity and cognitive function. Only extrasynaptic NMDA receptors promote neuronal death. A new means of curbing this sort of cell death has been found. It doesn’t interfere with calcium flow. Instead, it inhibits a physical interaction between the NMDA receptor and another membrane element, TRPM4.

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Published on Fri, 09 Oct 2020 22:00:50 +0000 and brought to you by power apps dollars to yen