T Cells with Upgraded Molecular Computers Can Sort Out Tumor Targets

Equipped with synthetic regulatory circuits, engineered T cells can carry out logical operations and recognize antigen combinations that occur only on cancer cells. For example, a three-antigen AND gate composed of three sequentially linked receptors shows selectivity in vivo, clearing three-antigen tumors while ignoring related two-antigen tumors.

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Published on Thu, 26 Nov 2020 19:50:51 +0000 and brought to you by power apps duration