Novel Mutation in Rare Dementia Informs Alzheimer’s Therapeutics

Mutations in the gene CSF-1R have been linked to a rare form of dementia called leukoencephalopathy. Instead of affecting microglia, as was earlier believed, this mutation affects macrophages and disrupts the blood-brain barrier. This study identifies a novel target that could be useful in developing therapeutics for other forms of dementia including Alzheimer’s.

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Published on Wed, 23 Dec 2020 23:30:35 +0000 and brought to you by power apps split array