The advent of next-generation sequencing has led to the rise of novel gene expression profiling methods like spatial transcriptomics. How will this revolutionary approach, powered by high-quality multi-omics biospecimen, impact personalized immuno-oncology therapy in the future?
Next-generation sequencing (NGS) technologies have revolutionized the way scientific research is conducted, triggering new research paradigms and providing novel clinical insights.
Developed as a result of NGS in 2013, spatial transcriptomics is a groundbreaking molecular profiling method, which visualizes the location of gene activity within a tissue – the ‘where’, in parallel to studying gene expression patterns – the ‘what’.
Spatial transcriptomics: a holistic insight into cellular expression
Conventional RNA sequencing techniques can help identify gene expression activity in a tissue, but often destroy the tissue in the process. And while traditional visualization techniques, such as in situ hybridization, can capture localized gene expression patterns, they are limited to examining a few genes at a time.
Spatial transcriptomics builds on a combination of these methods: marrying the depth of information from tools such as sequencing,
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Published on Tue, 23 Nov 2021 09:00:12 +0000 and sponsored by Apptigent PowerTools